Two new therapies approved for the treatment of atopic dermatitis

We are pleased to announce that two new treatments have been recently approved by the FDA for the treatment of atopic dermatitis. Oregon Medical Research Center and our patients contributed to the approval by enrolling in the pivotal studies that provided the data showing the benefits of the treatment options. We want to thank all of our patient volunteers who helped make this treatment available.

U.S. FDA Approves Pfizer’s CIBINQO® (abrocitinib) for Adults with Moderate-to-Severe Atopic Dermatitis

U.S. FDA Approves RINVOQ® (upadacitinib) to Treat Adults and Children 12 Years and Older with Refractory, Moderate to Severe Atopic Dermatitis


Dr. Andrew Blauvelt named as one of the world’s most influential scientists

Each year the consulting and data analysis firm Clarivate compiles an annual list of researchers who have demonstrated significant and broad influence reflected in the publication of multiple papers frequently cited by their peers.

The 2021 list includes about 3,800 researchers in 21 scientific fields, and another 2,800 researchers identified as having exceptional performance across several fields. The citation analysis considered only papers in journals indexed in the Web of Science Core Collection during the period from 2010 to 2020. Highly cited papers are defined as those that rank in the top 1% by citations for field and publication year. The method, papers weighed against others in the same annual cohort, is intended to remove the citation advantage of older papers relative to recently published ones.

Dr. Blauvelt’s ranking recognizes his ongoing dedication and expertise in psoriasis research.


New treatment approved for mild-to-moderate atopic dermatitis

A new cream for the treatment of patients with mild-to-moderate atopic dermatitis (also commonly called eczema) was recently approved by the FDA. The generic name of the medication is ruxolitinib, and the trade name is Opzelura®. Typical treatments for eczema patients are dominated by topical steroids, such as triamcinolone cream, which patients will often use for many years, sometimes never being offered any alternative treatments. Opzelura® cream is not a steroid (like triamcinolone), but it was shown in clinical trials to work as well as what one would expect from topical steroids. Importantly, Opzelura® cream was also not associated with problems normally associated with topical steroid use, like thinning of the skin and loss of response over time. Dr. Andrew Blauvelt, President of Oregon Medical Research Center (OMRC), also has served as an advisor to Incyte, the makers of Opzelura® cream, and has co-authored scientific publications on this new medication. OMRC greatly thanks the patients at our site who participated in the Opzelura® trials, and thus helped to bring this exciting new drug to the market for others.


The Psoriasis Pipeline

Recently, Dr. Andy Blauvelt, President of Oregon Medical Research Center (OMRC), was interviewed by the American Academy of Dermatology regarding upcoming drugs that will likely become available soon to treat psoriasis. Dr. Blauvelt, an international expert in psoriasis, has experience using all of these medications while participating in clinical trials for these drugs at OMRC. The article appeared in Dermatology World, a publication sent out to and read by most dermatologists in the country. Psoriasis Pipeline_ 08_21_DermWorld

(Article reprinted with permission from Dermatology World)



Clinical Trial Evaluating New Eczema Drug Shows Promising Results

Atopic dermatitis (AD), also known as eczema, is a common skin disease that significantly impacts quality of life. One of the most distressing symptoms of this disease is itching, which can often lead to disruption of the skin barrier and skin infection. OMRC recently participated in a 16-week study evaluating a new treatment for AD, called lebrikizumab, which is given by injection under the skin. Lebrikizumab blocks one protein in the body, interleukin 13, that is believed to be critical for causing AD. AD patients receiving lebrikizumab showed rapid improvement in both skin lesions and patient-reported itch. The study participants receiving the highest dose of lebrikizumab reported the most benefits, including significant reduction in itching as early as 2 days after the first injection. Furthermore, this new drug proved very safe over 16 weeks of treatment. More long-term AD studies with lebrikizumab are currently underway at OMRC and around the country. If positive, the drug may be approved and on the market for widespread use as early as 2022. Of note, Dr. Andrew Blauvelt, President of OMRC, is an author on this recent lebrikizumab publication.

Read the full study publication here: http://bit.ly/32R69EF