Relief for Genital Psoriasis

Yes, let’s talk “genital psoriasis,” even though many people don’t want to talk about it. Genital psoriasis, in both women and men, is hard to talk about, hard to treat, and has a big impact on intimate relationships as well as normal daily functioning. Up to 40% of psoriasis patients report lesions in the genital area. The good news is that a treatment, ixekizumab (Taltz), has been FDA-approved for genital psoriasis. More than 70% of patients treated for 3 months did well after starting this medication and responses were maintained for up to 1 year of continued treatment. I’m happy to say that the clinical research team at OMRC was key in bringing this study forward, completing it, and analyzing the data for publication. So, the bottom line is, don’t hide the fact that you may have genital psoriasis, but instead, ask your doctor about the possibility of effectively treating this often troubling and overlooked area of the body.


Comparison study shows efficacy of new targets

Several recent clinical trials in patients with moderate‐to‐severe psoriasis have demonstrated that inhibitors targeting IL‐17 and IL‐23 can offer patients high levels of skin clearance.

The IXORA‐R trial focuses on early responses to treatment. Because patients have indicated that rapid, complete clearance of psoriasis is a priority, the primary endpoint of IXORA‐R is complete clearance at Week 12, as measured by a 100% improvement in Psoriasis Area and Severity Index (PASI 100). Patients with moderate‐to‐severe plaque psoriasis were randomized 1:1 to receive either ixekizumab, brand name “Taltz,” an IL‐17 inhibitor, or guselkumab, brand name “Tremfya,” an IL‐23 inhibitor, at the approved doses. As of Week 12, the study findings demonstrate clinically meaningful and statistically significant differences in results for ixekizumab versus guselkumab in complete clearance (PASI 100) at Week 12. The rapid response of ixekizumab was demonstrated as early as Week 1. Additionally, ixekizumab treatment led to more rapid achievement of improved quality of life and resolved itch more rapidly than guselkumab. The safety profiles of ixekizumab and guselkumab were consistent with previous phase 3 studies of the drugs.

https://investor.lilly.com/news-releases/news-release-details/new-head-head-data-show-taltzr-ixekizumab-superiority-versus


New “botox” delivers!

DaxibotulinumtoxinA (“daxi”) is an investigational Botox®-like drug produced by the company Revance. Oregon Medical Research Center (OMRC) and our patient volunteers participated in a large national study funded by Revance where daxi was investigated for its ability to remove glabellar fold lines, the often-deep, perpendicular, skin wrinkles seen between the eyes. Over 3,000 patients were treated across the country, with over 60 participating here at OMRC. Remarkably, more than 95% of patients treated with daxi achieved a glabellar line score of zero or mild following a single injection of daxi. In addition, the effect lasted for an average of 7 months, much longer than what is normally seen with Botox®. The study also showed the drug to be safe. Because of the success of this trial, Revance has announced it will file daxi for approval with the FDA in 2019; the drug may then be available for widespread use in 2020.
https://investors.revance.com/news-releases/news-release-details/revances-rt002-demonstrates-unprecedented-efficacy-and-duration


Ilumya is now available!

Ilumya(TM) (tildrakizumab-asmn) is a new medication recently approved by the F.D.A. for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. 

We’ve partnered with patients for nearly 6 years on studies that have helped provide the data to show the outstanding results for patients on this treatment. We are happy to help bring another option to people who live with psoriasis.


New treatment approved for excessive sweating!

dermira-FDAWe are excited to announce that one of the clinical studies that we and our patients participated in met its ultimate goal: approval by the Federal Drug Administration (FDA). Qbrexza cloths will be available as a prescription beginning in October 2018.

Qbrexza cloths are the first new treatment for hyperhidrosis (excessive sweating) since 2011 and are approved for use in adults and children ages 9 and above. 

To learn more, visit https://sweathelp.org/sweatsolutions-newsletter/news-blog/413-finally-new-hyperhidrosis-treatment-fda-approved.html


Heart Attacks and Psoriasis

If you have psoriasis, it places you at a higher risk for having a heart attack when compared to someone who doesn’t have psoriasis. The old saying from a 1970’s TV commercial, “the heartbreak of psoriasis,” is true! If you have a little bit of psoriasis, then the risk is a little bit. If you have a medium amount of psoriasis, then the risk is medium, and if you have a lot of psoriasis, your risk for a heart attack is high. Why is this the case? The amount of inflamed skin due to psoriasis that we can see with our eyes is directly correlated with the amount of inflamed tissue that occurs on the inside of the body. More specifically, inflammation from the skin spills into the bloodstream and causes the inner linings of arteries to become inflamed. This, in turn, makes the arteries more likely to become blocked, which can then lead to things like heart attacks and strokes. Emerging new evidence suggests that treatments for psoriasis, like the biologics Stelara and Cosentyx, improve the skin and are then likely to decrease the risk of heart attacks. This makes psoriasis much more than a cosmetic skin disease, and more of a general health issue, for those who suffer from it. Get your psoriasis cleared up and improve your overall health.Publications